SadPhos ligand is a newly developed chiral ligand with adaptive coordination, created by the research group of Professor Zhang Junliang. This ligand features non-C2 symmetry and various coordination atoms with differing soft and hard properties. It can be used as a monophosphine ligand, or as an N,P-ligand, P,S-ligand, and P,O-ligand,...

In August 2018, the team led by Academician Shao Feng, deputy director of the Beijing Institute of Life Sciences, published a groundbreaking research paper titled "Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose" in Nature. The study was the first to demonstrate that adenosine heptose monophosphate (ADP-heptose)...

Gold nanorods are rod-shaped nanoparticles made of gold, with dimensions ranging from a few nanometers to hundreds of nanometers. These nanoparticles have unique and rich physical and chemical properties, such as high surface electric field intensity enhancement and tunable photothermal conversion efficiency. These properties make gold nanorods ideal for applications...

Studying the spatial distribution of proteomes in cells is crucial for understanding various molecular mechanisms in cell biology. In recent years, proximity chemical labeling technology, especially APEX (Engineered Ascorbate Peroxidase), has rapidly advanced. This method enables proximity labeling of proteins and RNA in specific spatial regions within living cells, avoiding...

High-fidelity in vivo fluorescence monitoring of physiological processes is crucial in disease diagnosis and biological research, but it faces extreme challenges due to aggregation-induced quenching (ACQ) and short-wavelength fluorescence. The development of high-performance, long-wavelength aggregation-induced emission (AIE) fluorophores has placed higher demands on precise optical bioimaging.Chromophore-quinoline-malononitrile (quinolinenitrile, QM) is a...

FM series fluorescent dyes include FM 1-43, FM 2-10, FM 5-95, and FM 4-64. They are a type of lipophilic styrene fluorescent dyes that are non-toxic to cells and are mainly used for living cell membranes, especially plant samples. Specific labeling of cell membranes, tracer imaging of neuronal cells, and...