EC series near-infrared fluorescent dyes are a new class of high-performance dyes developed by the research team of Professor Yang Youjun at East China University of Science and Technology (Figure 1) [1-7]. These dyes are designed to meet the growing demand for infrared imaging, photothermal ablation, and other applications in...

The reverse transmembrane pH gradient in cancer cells is a crucial target for disease treatment and can be leveraged for intraoperative histopathological analysis. However, the pathologically relevant pH changes in these cells are subtle and undetectable using traditional Henderson-Hasselbalch-type pH fluorescent probes. To overcome this limitation, Professor Yang Youjun’s team...

SadPhos ligand is a newly developed chiral ligand with adaptive coordination, created by the research group of Professor Zhang Junliang. This ligand features non-C2 symmetry and various coordination atoms with differing soft and hard properties. It can be used as a monophosphine ligand, or as an N,P-ligand, P,S-ligand, and P,O-ligand,...

In August 2018, the team led by Academician Shao Feng, deputy director of the Beijing Institute of Life Sciences, published a groundbreaking research paper titled "Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose" in Nature. The study was the first to demonstrate that adenosine heptose monophosphate (ADP-heptose)...

Gold nanorods are rod-shaped nanoparticles made of gold, with dimensions ranging from a few nanometers to hundreds of nanometers. These nanoparticles have unique and rich physical and chemical properties, such as high surface electric field intensity enhancement and tunable photothermal conversion efficiency. These properties make gold nanorods ideal for applications...

Studying the spatial distribution of proteomes in cells is crucial for understanding various molecular mechanisms in cell biology. In recent years, proximity chemical labeling technology, especially APEX (Engineered Ascorbate Peroxidase), has rapidly advanced. This method enables proximity labeling of proteins and RNA in specific spatial regions within living cells, avoiding...