Trifluoromethyl is an important structure. Introducing it into organic compounds can improve the polarity, dipole moment, stability, and lipophilicity of the target product. Therefore, compounds containing trifluoromethyl are widely used in medicines and pesticides. , new materials and other fields are of great significance. Methyl fluorosulfonyl difluoroacetate (also known as...

Carbodiimide (R1-N=C=N-R2) is a novel organic synthon with a special azaalne structure and electronic properties. Therefore, it exhibits novel and rich reaction characteristics. It was previously reported that the two active sites of carbodiimide are the central carbon atom and the C=N double bond. Professor Zhang Wenxiong’s research group from...

Autophagy is an important cell signaling pathway related to many physiological and pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer. A common autophagy inhibitor is 3-Methyladenine (3-MA), which inhibits the formation of autophagosomes by inhibiting PI3K. Its concentration needs to be in the mM level each...

      Spiroaromatic hydrocarbons are an important class of organic semiconductor building units. Their unique non-planar spiro conjugation effect, cross conformation and steric hindrance effect can effectively improve the optoelectronic properties and device stability of organic semiconductor materials. The one-pot preparation method of spirobifluorene xanthene (SFX) [1,2] has the...

      Fluorine-containing molecules have been widely used in modern medicines, pesticides and materials. For example, the selective addition of a fluoroalkyl group to drugs or bioactive molecules often significantly alters their metabolic stability, lipophilicity, and bioactivity. Therefore, there has been considerable interest in developing new and efficient methods...

      Fluorine is an important non-metal element. Due to its unique electronegativity, electronic effect and steric hindrance effect, fluorine atoms are often introduced into drugs to regulate drug metabolism pathways, improve metabolic stability and permeability, etc., and have been More than 20% of drugs and pesticides on the...