In August 2018, the team led by Academician Shao Feng, deputy director of the Beijing Institute of Life Sciences, published a groundbreaking research paper titled "Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose" in Nature. The study was the first to demonstrate that adenosine heptose monophosphate (ADP-heptose) acts as a true pathogen-associated molecular pattern (PAMP). ADP-heptose can penetrate mammalian cell membranes and is recognized by the novel immune receptor kinase ALPK1, which serves as a pattern recognition receptor (PRR). This recognition triggers the NF-κB-mediated innate immune inflammatory response[1][1][1]

Product number：9020852
ADP-heptose, 95%
ADP-Heptose

About Dr. Li Chao: Dr. Li Chao is a senior researcher at the Beijing Institute of Life Sciences, focusing on several research areas:

1. Developing novel chemical bond construction methods using advanced catalytic systems to enhance molecule synthesis strategies.
2. Synthesizing and optimizing the activity of natural products related to major diseases, contributing to innovative drug research.
3. Investigating the biological mechanisms and targets of active natural small molecules.
4. Designing chemical tool molecules for selective labeling, tracking of biological macromolecules, and identifying molecular interactions.

Reference

• Zhou, P., et al. Nature. 2018, 561, 122-126.