Click Chemistry is a synthesis concept proposed by Sharpless, a Nobel Prize winner in chemistry from the United States, in 2001 [1]. Among them, the main and classic click chemical reaction is the Cu(I)-catalyzed azide-alkynyl Husigen cycloaddition reaction (CuAAC). This reaction has the advantages of high yield, few side reactions,...

Qinheng Zheng Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA Click chemistry and drug discovery are a perfect match One of the most profound advancements of modern chemistry is click chemistry. Ranked top of the most cited papers in the history of chemistry is...