Intraoperative fluorescence navigation is a cutting-edge technology that leverages the enhanced penetration and retention effect (EPR effect) of fluorescent dyes. These dyes accumulate in tumor tissue and emit fluorescence upon receiving excitation light, allowing for real-time visualization of tumor locations during surgery.    Figure 1 Fluorescence imaging technology has broad...

The reverse transmembrane pH gradient in cancer cells is a crucial target for disease treatment and can be leveraged for intraoperative histopathological analysis. However, the pathologically relevant pH changes in these cells are subtle and undetectable using traditional Henderson-Hasselbalch-type pH fluorescent probes. To overcome this limitation, Professor Yang Youjun’s team...

In August 2018, the team led by Academician Shao Feng, deputy director of the Beijing Institute of Life Sciences, published a groundbreaking research paper titled "Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose" in Nature. The study was the first to demonstrate that adenosine heptose monophosphate (ADP-heptose)...

Gold nanorods are rod-shaped nanoparticles made of gold, with dimensions ranging from a few nanometers to hundreds of nanometers. These nanoparticles have unique and rich physical and chemical properties, such as high surface electric field intensity enhancement and tunable photothermal conversion efficiency. These properties make gold nanorods ideal for applications...

Studying the spatial distribution of proteomes in cells is crucial for understanding various molecular mechanisms in cell biology. In recent years, proximity chemical labeling technology, especially APEX (Engineered Ascorbate Peroxidase), has rapidly advanced. This method enables proximity labeling of proteins and RNA in specific spatial regions within living cells, avoiding...

FM series fluorescent dyes include FM 1-43, FM 2-10, FM 5-95, and FM 4-64. They are a type of lipophilic styrene fluorescent dyes that are non-toxic to cells and are mainly used for living cell membranes, especially plant samples. Specific labeling of cell membranes, tracer imaging of neuronal cells, and...