Ligands play a pivotal role in asymmetric synthesis by bonding with central metal atoms through coordination or covalent bonds. This interaction modifies the chemical environment surrounding the metal, thereby optimizing reaction conditions, enhancing catalytic activity, and improving conversion rates. To date, scientists have developed thousands of chiral ligands to facilitate...

Ordered Mesoporous Materials: Unlocking New Frontiers in Science and Industry Ordered mesoporous materials have demonstrated immense potential across various fields, including catalysis [1], adsorption, separation, energy conversion and storage [2], environmental processing [3], sensing, information technology, electronic devices [4], and biomedicine [5]. These materials exhibit exceptional properties such as: Large...

Cutting-Edge Mesoporous Materials by Zhao Dongyuan: Revolutionizing Applications in Science and Industry On November 3, 2021, the project "Creation and Application of Ordered Mesoporous Polymers and Carbon Materials" led by Zhao Dongyuan, an academician of the Chinese Academy of Sciences and professor at Fudan University's Department of Chemistry, was awarded...

Innovative Deuterated Methylated Aromatics by Professor Zhou Qianghui: Transforming Medicinal Chemistry Methyl groups are commonly found in small-molecule drugs and play a vital role in enhancing drug properties. Numerous studies demonstrate that introducing methyl groups at specific sites in candidate drugs can: Improve metabolic stability, Shorten half-life, Enhance solubility and...

Efficient Synthesis of Pyridone and Quinolinone Skeletons for Medicinal Chemistry Pyridone and quinolinone skeletons are essential components in numerous natural products and drug molecules. Examples include the antibiotic Diazaquinomycin B and Benzosimuline, a natural product with anti-platelet aggregation activity. The efficient and selective synthesis of these skeletons holds immense potential...

Mitochondria-Targeted Research with IR-780 Ethyl Iodide Mitochondria are fundamental organelles in eukaryotic cells, playing a crucial role in energy metabolism. Positively charged dyes are commonly used for mitochondrial labeling in living cells, offering innovative methods to study mitochondrial metabolic processes. IR-780 Ethyl Iodide (λex = 780 nm, λem = 830...