Ligands play a critical role in asymmetric synthesis by bonding with central metal atoms through coordination or covalent bonds. These interactions influence the chemical environment around the metal, improving reaction conditions, enhancing catalytic activity, and increasing conversion rates. To date, thousands of chiral ligands have been developed to advance research in this field.

The SadPhos Ligand Family

Since 2014, Professor Zhang Junliang’s research group has been at the forefront of developing the SadPhos ligand family. These ligands are a new type of chiral ligand featuring adaptive coordination and non-C2 symmetry. They exhibit a variety of soft and hard coordination atoms, enabling flexible coordination modes. The SadPhos ligands can function as:

• Monophosphine ligands,
• N,P-ligands,
• P,S-ligands, and
• P,O-ligands.

This adaptability allows them to coordinate with numerous transition metals and metals in various valence states, providing exceptional versatility in asymmetric synthesis.

Evolution of the SadPhos Family

Over nine years of development, the SadPhos ligand family has grown significantly. Starting with Ming-Phos in 2014, the series now includes:

• Ming-Phos (2014),
• Xiao-Phos (2015),
• Wei-Phos (2015),
• Peng-Phos (2016),
• Xiang-Phos (2016),
• PC-Phos (2017),
• Xu-Phos (2018),
• WJ-Phos (2019),
• Le-Phos (2019),
• TY-Phos (2020),
• GF-Phos (2021),
• W-Phos (2022), and
• Rong-Phos (2023).

The SadPhos family has been extensively studied and cited in over 100 articles published in leading international journals.

Spotlight on Ming-Phos

The Ming-Phos ligand, named after Dr. Zhang Zhanming, is the first member of the SadPhos family. It has shown outstanding performance in asymmetric reactions catalyzed by transition metals such as gold, copper, silver, and palladium, demonstrating remarkable selectivity. This ligand is a cornerstone in the development of subsequent SadPhos ligands, setting a high standard for asymmetric synthesis.

J&K Scientific’s Offerings

J&K Scientific supplies a variety of Ming-Phos ligands with the following benefits:

• Comprehensive Product Range:
  Including chiral ligands, metal catalysts, organic molecular catalysts, chiral building blocks, prosthetic groups, chiral reagents, and separation reagents.
• Cutting-Edge Solutions:
  Offering new chiral ligands and catalysts derived from the latest research by experts in the field.
• High-Quality Standards:
  Guaranteed high purity, strict quality control, and stable batch-to-batch consistency.
• Advanced Characterization:
  Products undergo thorough identification via hydrogen nuclear magnetic resonance spectroscopy and phosphorus spectroscopy.

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