Because they contain diazomethane functional groups, trifluoromethyldiazomethane (CF3CHN2), difluoromethyldiazomethane (CHF2CHN2) and formyldiazomethane (CHOCHN2) are used as highly active trifluoromethylated and difluoromethylated compounds, respectively. Methylation and formylation reagents are widely used in the efficient synthesis of organic fluorine compounds and aldehydes. However, all three are gases, which are toxic, volatile, and...
11
Dec
Formyldiazomethane (CHOCHN2) and difluoromethyldiazomethane (CHF2CHN2) are two types of low molecular weight, easily volatile functionalized diazomethane derivatives. Taking advantage of the rich reactivity of diazomethane groups, they can introduce difluoromethyl or aldehyde groups into organic molecules. However, these two types of diazo compounds have the disadvantages of being gases under...
11
Dec
Trifluoromethyldiazomethane (CF3CHN2) is an important precursor for introducing trifluoromethyl into organic molecules and is widely used in organic synthetic chemistry. However, there is only one way of producing it, and its storage convenience and use Security has always been a problem that is difficult to solve with traditional methods (see...
11
Dec
Commonly used SO2 replacement reagents include Na2SO3, Na2S2O5 (or K2S2O5), HOCH2SO2Na·2H2O and DABSO, etc. Among them, Na2SO3 needs to be used in combination with concentrated sulfuric acid, and the process of releasing SO2 will generate severe heat; inorganic sulfate salts often require high temperature and phase transfer catalysts; HOCH2SO2Na·2H2O is...
11
Dec
γ-Ketosulfones can serve as key bioactive components of antibacterial, anticoagulant and antitumor drugs and play an important role in medicinal chemistry. Traditional γ-ketosulfones are obtained by oxidation of the corresponding γ-ketothioethers or derivatization of alkyl or aryl sulfinates. However, the steps are cumbersome and require the use of strong oxidants,...
11
Dec
Among various organosulfur compounds, sulfones are not only ubiquitous in many biomolecules and drugs but can also be used as versatile building blocks in synthetic chemistry. Trifluoromethylthio (-SCF3) is often used as a dominant structure in drug design and synthesis.Professor Lian Zhong of Sichuan University developed a Cu-catalyzed multi-component reaction...
