Imaging technology based on organic small molecule fluorescent dyes has been widely used in functional molecular labeling and detection as an intuitive and in-situ visual observation technology.However, the Stokes shift of most common fluorescent dyes (such as fluorescein, rhodamine, oxazine, and cyanine) is very small (generally <30 nm), resulting in...

The research group of Zhang Xiaobing and Yuan Lin of Hunan University developed a fluorescent dye with high brightness, high photostability and large Stokes shift - YueLu dyes. YLs), the active intermediate of this dye (YL578-NHS) can be used for protein labeling; the Halo protein labeling (YL578-Halo and 10-Halo) probes...

Fluorine is an important non-metal element. Due to its unique electronegativity, electronic effect and steric hindrance effect, fluorine atoms are often introduced into drugs to regulate drug metabolism pathways, improve metabolic stability and permeability, etc., and have been More than 20% of drugs and pesticides on the market contain one...

Mimicking the active site and substrate binding cavity of enzymes to achieve specificity in catalytic reactions is an important challenge. The research group of Professor Fang Yu of Hunan University has newly developed a phenothiazine-based octahedral porous coordination cage supramolecular photocatalytic material (PCC-6-M), which regulates the generation path of reactive...

Metal-organic frameworks (MOFs) are a type of crystalline porous material with a periodic network structure formed by interconnecting inorganic metal centers (metal ions or metal clusters) and bridging organic ligands through self-assembly. Because of its excellent characteristics such as structural diversity, porosity, and high specific surface area, it has broad...

The research group of Professor Fang Yu of Hunan University used the phenothiazine-based octahedral porous coordination cage (PCC-6-Zn) in the zinc metal center to produce a single singlet oxygen to participate in the reaction [1], achieving C under light conditions. Selective oxidation of (sp3)-H bonds and the synthesis of a...