ATP (adenosine triphosphate) is the main source of energy for cellular activities. In mitochondria, ATP causes irreversible changes in mitochondrial function through a series of chemical and biosynthetic processes (ie, oxidative phosphorylation), leading to the occurrence of many diseases such as ischemia, Parkinson's disease, and malignant tumors. Therefore, in order to indicate the function of ATP in normal or diseased states, there is an urgent need to develop a fluorescent probe to accurately monitor dynamic changes in mitochondrial ATP levels.

The Rh6G-ACFPN fluorescent probe (Figure 1) developed by the Zhang Xiaobing-Yuan Lin team can activate ATP in a ratiometric and reversible response, and can monitor and quantify mitochondrial ATP levels in living cells in real time [1][1][1].

Professor Yuan Lin is a professor and doctoral supervisor at the School of Chemistry and Chemical Engineering, Hunan University and the State Key Laboratory of Chemical Biosensing and Metrology.Currently, he has published more than 100 papers in international academic journals, with a total citation of more than 12,000 times, and an h-index of 58.Among them, the first or corresponding author from 2012 to presentJ. Am. Chem. Soc.（10 articles）、 Nat. Commun.（1 articles）、 Angew. Chem. Int. Ed.（10 articles）、CCS Chem.（1 articles）、Chem. Sci.（4 articles）、Anal. Chem.（10 articles）、Adv. Funct. Mater、BiomaterialsPublished more than 70 papers in journals and other journals. Mainly engaged in research on small molecule fluorescent probes and their applications.

Product list

ACF-ATP-4

2413986-07-7

9332555
2 MG

References

1. Ren, T. B.; Wen, S. Y.; Wang, L.; Lu, P.; Xiong, B.; Yuan, L.; Zhang, X. B. Anal. Chem. 2020, 92 (6), 4681– 4688.