Adenosine triphosphate (ATP) is the primary energy carrier in cellular activities. In mitochondria, ATP drives essential biochemical and biosynthetic processes, such as oxidative phosphorylation, which can significantly impact mitochondrial function. Abnormal ATP metabolism is linked to several severe diseases, including ischemia, Parkinson’s disease, and malignant tumors.
To better understand ATP’s role in both normal and diseased states, there is an urgent need for a fluorescent probe capable of accurately detecting dynamic changes in mitochondrial ATP levels.
The Rh6G-ACFPN fluorescent probe (Figure 1), developed by the Zhang Xiaobing-Yuan Lin research group, provides ratiometric and reversible activation of ATP. This enables real-time monitoring and quantification of mitochondrial ATP levels in living cells [1][1][1].
Professor Yuan Lin is a professor and doctoral supervisor at the School of Chemistry and Chemical Engineering, Hunan University and the State Key Laboratory of Chemical Biosensing and Metrology.Currently, he has published more than 100 papers in international academic journals, with a total citation of more than 12,000 times, and an h-index of 58.Among them, the first or corresponding author from 2012 to presentJ. Am. Chem. Soc.（10 articles）、 Nat. Commun.（1 articles）、 Angew. Chem. Int. Ed.（10 articles）、CCS Chem.（1 articles）、Chem. Sci.（4 articles）、Anal. Chem.（10 articles）、Adv. Funct. Mater、BiomaterialsPublished more than 70 papers in journals and other journals. Mainly engaged in research on small molecule fluorescent probes and their applications.
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References
- Ren, T. B.; Wen, S. Y.; Wang, L.; Lu, P.; Xiong, B.; Yuan, L.; Zhang, X. B. Anal. Chem. 2020, 92 (6), 4681– 4688.
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