Fluorine is a vital non-metal element widely used in pharmaceuticals and agrochemicals. Due to its unique electronegativity, electronic effects, and steric hindrance, fluorine atoms are often introduced into drug molecules to enhance metabolic stability, permeability, and bioavailability. Over 20% of commercially available drugs and pesticides contain one or more fluorine...

Achieving specificity in catalytic reactions by mimicking the active sites and substrate-binding cavities of enzymes is a significant scientific challenge. Professor Fang Yu's research group at Hunan University has developed an innovative supramolecular photocatalytic material, PCC-6-M, based on phenothiazine and octahedral porous coordination cages. This material enables the regulation of...

Metal-organic frameworks (MOFs) are crystalline porous materials with a periodic network structure, formed through the self-assembly of inorganic metal centers (metal ions or metal clusters) and bridging organic ligands. Due to their structural diversity, high porosity, and large specific surface area, MOFs hold immense potential across various research fields, including...

The research group led by Professor Fang Yu at Hunan University has successfully developed a novel catalyst, PCC@THF-OOH, which achieves light-dark catalytic coupling. This breakthrough is based on a phenothiazine-based octahedral porous coordination cage (PCC-6-Zn), where the zinc metal center selectively generates singlet oxygen for oxidation reactions under light conditions...

Trifluoromethyldiazomethane (CF₃CHN₂), difluoromethyldiazomethane (CHF₂CHN₂), and formyldiazomethane (CHOCHN₂) are widely used as highly reactive reagents for trifluoromethylation, difluoromethylation, and formylation in the synthesis of organic fluorine compounds and aldehydes. However, these gases are toxic, volatile, and explosive, posing significant safety risks during production, storage, and use. Managing these safety concerns has...

Formyldiazomethane (CHOCHN₂) and difluoromethyldiazomethane (CHF₂CHN₂) are highly reactive, low-molecular-weight compounds widely used to introduce difluoromethyl or aldehyde groups into organic molecules. Despite their value, these functionalized diazomethane derivatives pose significant safety risks due to their gaseous state, volatility, toxicity, and explosiveness under standard conditions. Existing production methods require handling explosive...