Chemotherapy is currently the main means of treating cancer, but tumor cells may develop drug resistance, and the mechanism is complex. High levels of reduced glutathione (GSH) may be an important reason for this phenomenon. To reveal the detailed role of GSH in chemoresistance, it is crucial to find a...

Peroxynitrite anion (ONOO-) plays a key regulatory role in many physiological processes and is closely related to the occurrence of oxidative damage, ischemic stroke, neurodegenerative diseases, cancer and other diseases.In order to explore the biological mechanism of ONOO- in disease occurrence, it is particularly critical to find a method that...

Changes in intracellular and intracellular pH play an important role in physiological and pathological processes. Changes in intracellular pH can easily induce cell division, rapid growth and functional disorders. The reduction of extracellular pH to acidic is an important signal for cancer and other lesions. Therefore, the detection of pH...

Mitophagy is the process by which cells remove damaged or aged mitochondria and recycle their constituent elements. It is closely related to many physiological and pathological processes such as aging, neurodegenerative diseases, and cancer, so the study of mitophagy is of great significance.Currently, two methods are mainly used to study...

Nitrogen-containing compounds widely exist in natural products, drugs, functional materials and other fields, so the efficient construction of C-N bonds has attracted much attention. Traditionally, the formation of amide groups mainly relies on the homocleavage of N-X bonds, but N-X bonds are difficult to construct under harsh conditions, which fundamentally...

Chromones and their derivatives are ubiquitous in natural products. This heterocyclic compound shows a variety of pharmacological properties and is one of the important frameworks for drug development. So far, scientists have synthesized a variety of functionalized chromones, especially C3-functionalized chromones. Studies have shown that 3-aminochromone has biological activities such...