Sugar nucleotides are formed by connecting the reducing end of a monosaccharide to the terminal phosphate group of a nucleoside diphosphate (or nucleoside monophosphate), and are the activated form of a monosaccharide. It can serve as a donor substrate for glycosyltransferases and participate in the enzymatic synthesis of complex oligosaccharides...

Hyaluronan (HA) and chondroitin (CH) are two important glycosaminoglycans that are widely present on the cell surface and extracellular matrix. They can interact with cytokines, cell adhesion molecules, selectins, and enzymes to regulate intracellular signaling pathways [1]. At the same time, it is also widely used in medicine, cosmetics and...

Asymmetric catalysis is one of the most active branches in modern organic chemistry research, and asymmetric catalytic reactions are considered to be the most efficient methods for synthesizing chiral substances. The principle is to convert achiral raw materials into chiral products by using chiral catalysts. Therefore, the chiral ligand complexed...

Ligands can bond with metal central atoms through coordination or covalent bonds, directly affecting the chemical environment around metal atoms, thereby improving reaction conditions, catalytic activity and conversion rates. So far, scientists have developed Thousands of chiral ligands. Among them, chiral oxazoline ligands have the advantages of diverse structures, easy...

Chemical cross-linking coupled with mass spectrometry (CXMS) has been booming in the past decade and is widely used in protein structure identification and protein interaction analysis. However, the chemical cross-linking agents available for CXMS technology are limited and the cross-linking efficiency is not high enough, which limits the application of...

Chemical cross-linking coupled with mass spectrometry (CXMS) is widely used in protein interaction analysis, structure identification and kinetic studies. However, there are fewer types of cross-linking agents available for CXMS, which mainly target protein N-termini and lysine residues, resulting in limited structural information that this technology can provide.Arginine is abundant...