The disulfide skeleton containing two covalently linked sulfur atoms is an important molecular structure in life sciences, medical sciences, and food chemistry due to its unique pharmacological and physicochemical properties (Figure 1). For example, disulfide bonds in biomolecules play various roles in various biochemical redox processes; the secondary and tertiary...

Sulfur-containing compounds occupy a very important position in the fields of food science, life science, pharmaceutical science, and materials science. However, the synthesis of sulfur-containing compounds presents many challenges [1]:Traditional methods of preparing sulfur-containing compounds use mercaptans and thiophenols, which not only have an unpleasant odor, but also often deactivate...

Fluorine is an important non-metal element. Due to its unique electronegativity, electronic effect and steric hindrance effect, fluorine atoms are often introduced into drugs to regulate drug metabolism pathways, improve metabolic stability and permeability, etc., and have been More than 20% of drugs and pesticides on the market contain one...

Trifluoromethylthio group is one of the most lipophilic groups. Introducing it into small molecule compounds can significantly enhance the ability of molecules to penetrate lipid membranes and increase the absorption rate in the body (Figure 1). Therefore, incorporating trifluoromethyl sulfide (CF3S) into drug candidates has become an important strategy for...

In recent years, the synthesis and application of aromatic hydrocarbons with zigzag rings connected head to tail by benzene rings have been widely explored. Extended zonal hydrocarbons replace part of the six-membered rings in zonal hydrocarbons with non-six-membered rings, and have attracted much attention due to their unique structures. Figure...

Heterocalixarene and crown arene are two new types of synthetic macrocyclic main molecules. Heterocalixarene has a finely adjustable 1,3-alternating conformation structure and V-shaped macrocyclic cavity [1], and crown arene has a cylindrical shape. Heterocalixarenes and crownarenes composed of cavities, different heteroatoms, aromatic rings and aromatic heterocycles exhibit rich and unique...