Trifluoromethyldiazomethane (CF₃CHN₂) is a crucial precursor for introducing trifluoromethyl groups into organic molecules, widely applied in organic synthesis. Despite its importance, traditional production methods present significant challenges in storage, safety, and handling risks (see Figure 1). To solve these issues, Professor Bi Xihe’s research group at the School of Chemistry,...

In organic synthesis, sulfur dioxide (SO₂) is a crucial reagent, but commonly used SO₂-releasing compounds come with significant limitations: Sodium sulfite (Na₂SO₃): Requires concentrated sulfuric acid, generating excessive heat. Sodium metabisulfite (Na₂S₂O₅) & potassium metabisulfite (K₂S₂O₅): Often demand high temperatures and phase transfer catalysts. Sodium hydroxymethylsulfonate (HOCH₂SO₂Na·2H₂O): Highly hygroscopic, leading...

γ-Ketosulfones are crucial building blocks in medicinal chemistry, serving as key bioactive components in antibacterial, anticoagulant, and antitumor drugs. However, traditional synthesis methods typically involve: Oxidation of γ-ketothioethers: Requires strong oxidants and harsh conditions. Derivatization of sulfinates: Involves cumbersome, multi-step processes. These limitations hinder broader applications, making it difficult to...

Sulfones are widely found in biomolecules and pharmaceuticals, serving as essential building blocks in synthetic chemistry. Similarly, the trifluoromethylthio (-SCF₃) group plays a crucial role in drug design and synthesis due to its strong electron-withdrawing properties. Professor Lian Zhong from Sichuan University has developed a Cu-catalyzed multicomponent reaction that enables...

Organometallic chemistry focuses on the synthesis, structure, reaction, properties and applications of metal-organic compounds, and plays an important role in promoting the development of human society. Metallo-organic compounds are complexes composed of a central metal atom and ligands surrounding the metal atom. Carbonlon is a new type of chain polyyne...

Organometallic chemistry focuses on the synthesis, structure, reaction, properties and applications of metal-organic compounds, and plays an important role in promoting the development of human society. Metal-organic compounds are complexes composed of a central metal atom and ligands surrounding the metal atom. Carbolong Complexes are a planar conjugated carbon chain...