Fluorine is a vital non-metal element widely used in pharmaceuticals and agrochemicals. Due to its unique electronegativity, electronic effects, and steric hindrance, fluorine atoms are often introduced into drug molecules to enhance metabolic stability, permeability, and bioavailability. Over 20% of commercially available drugs and pesticides contain one or more fluorine atoms. As a result, the green and efficient synthesis of fluorinated compounds has become a major research focus in fluorine chemistry.
Professor Bi Xihe from Northeast Normal University has developed two innovative solid fluorination reagents—trifluoroacetaldehyde N-trifluoromethylbenzenesulfonylhydrazone (TFHZ-Tfs) and N-(o-trifluoromethyl)dihydrazone fluoroacetaldehyde benzenesulfonylhydrazone (DFHZ-Tfs). These reagents serve as precursors to gaseous fluorination agents trifluoromethyldiazomethane and difluoromethyldiazomethane, allowing for precise control over their generation rates. This controlled release mechanism enhances safety, making storage and usage significantly more reliable.
Comprehensive Fluorination Solutions by J&K Scientific
J&K Scientific offers a wide range of reagents essential for the synthesis and transformation of fluorine-containing compounds:
- Extensive Product Line: Covering fluorinated reagents, fluorinated building blocks, catalysts, ligands, alkynes, boron-containing compounds, organometallic reagents, synthetic reagents, and more. We also provide essential inorganic reagents, ultra-dry solvents, NMR solvents, and laboratory consumables.
- Innovative Fluorination Reagents: Supporting the latest scientific advancements in fluorine chemistry with new-generation fluorinating agents.
- Guaranteed Quality: High-purity products with rigorous quality control to ensure batch-to-batch consistency and reliability.
Recommended products
| Product name | CAS | Item number |
|---|---|---|
| Difluoroacetaldehyde N-triftosylhydrazone, 98% | 2245235-35-0 | 9171852 |
| TFHZ-Tfs, 98% | 2236129-81-8 | 9025326 |
Fluorine-containing blocks
| Product name | CAS | Item number |
|---|---|---|
| (Trifluoromethoxy)benzene, 99% | 456-55-3 | 237816 |
| Fluorobenzene, 99% | 462-06-6 | 514999 |
| 1,1,1-Trifluoro-3-phenyl-2-propanone, 97% | 350-92-5 | 503875 |
Catalysts and ligands
| Product name | CAS | Item number |
|---|---|---|
| Chloro(1,5-cyclooctadiene)rhodium(I) dimer, 98% | 12092-47-6 | 500156 |
| Nickel(II) bromide, dimethoxyethane adduct, min. 97% | 28923-39-9 | 28-1145 |
| Tris(4-fluorophenyl)phosphine, 98% | 18437-78-0 | 342295 |
Photocatalysts
| Product name | CAS | Item number |
|---|---|---|
| (2,2'-Bipyridine)bis[2-pyridinyl-kN)phenyl-kC]iridium(III) hexafluorophosphate, 99% | 106294-60-4 | 77-0465 |
| Eosin Y | 15086-94-9 | 985235 |
| Rhodamine B, 96% | 81-88-9 | 603231 |
Alkynes
| Product name | CAS | Item number |
|---|---|---|
| Cyclohexylacetylene, 98% | 931-48-6 | C38079 |
| 5-Decyne, 98% | 1942-46-7 | 995332 |
| 3-Methyl-1-butyne, 95% | 598-23-2 | 796593 |
Boron-containing compounds
| Product name | CAS | Item number |
|---|---|---|
| 4-Aminophenylboronic acid pinacol ester, 98% | 214360-73-3 | 205857 |
| Phenylboronic acid, 99% | 98-80-6 | 390913 |
Organometallic reagents
| Product name | CAS | Item number |
|---|---|---|
| Isopropylmagnesium bromide, 2.0 M solution in 2-MeTHF, J&KSeal | 920-39-8 | 967342 |
| Lithium diisopropylamide, 2.0 M solution in THF/n-heptane/ethylbenzene (22%/35%/14%), J&KSeal | 4111-54-0 | 982171 |
| Phenylmagnesium bromide, 2.9 M solution in 2-MeTHF, J&KSeal | 100-58-3 | 968141 |
Synthetic reagents
| Product name | CAS | Item number |
|---|---|---|
| Diisobutylaluminum hydride, 1.0 M solution in hexanes, J&Kseal, Colorless | 1191-15-7 | 997665 |
| Iodomethane, 99%, stabilized with copper chip | 74-88-4 | 395069 |
| Triethylamine, 99.7%, HPLC grade | 121-44-8 | 983728 |
Other Product
| Product name | CAS | Item number |
|---|---|---|
| Cerium(III) chloride, 99.9%, anhydrous | 7790-86-5 | 125652 |
| 1,4-Dioxane, 99.5%, SuperDry, with molecular sieves, stabilized with BHT, J&Kseal, Peroxides:≤0.03% | 123-91-1 | 972869 |
| Magnetic stir bar, PTFE-coated, egg-shaped, A100 (6*10mm), 5 pcs/pack | / | 1482821 |
向阳 翟
