Azasaccharides are a class of sugar mimetics with important biological and pharmacological activities and play an important role in glycochemistry and glycobiology [1]. Studies have shown that azasugar exhibits excellent glycosidase inhibitory activity, glycosyltransferase inhibitory activity and nucleoside phosphorylase inhibitory activity. Therefore, azasugar has broad application prospects in the treatment...

In August 2018, the team of Academician Shao Feng, deputy director of the Beijing Institute of Life Sciences, published a research paper titled "Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose" in Nature, proving for the first time that two Adenosine heptose monophosphate (ADP-heptose) can be used...

Rare earth extractant J&K Scientific sells a series of phosphonate rare earth extractants (P227, C272, P507) developed by Professor Xiao Jichang of the Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences. Compared with industrial grade (purity of about 90%), high-purity rare earth extractants (purity of 95-99%) are more effective...

Benzo[a]pyrene (B[a]p) is a typical polycyclic aromatic hydrocarbon with strong teratogenic, carcinogenic and mutagenic properties. After entering the human body, it undergoes a series of metabolic activation to generate 7,8-diol-9, 10 Epoxy benzopyrene (benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide, BPDE). This metabolite has two pairs of enantiomers: (±)anti-BPDE and (±)syn-BPDE. A large number of studies...

Alkynylamide condensation reagents (Figure 1) are a type of reagent with a new structure developed by Professor Zhao Junfeng's research group and are used for the direct condensation of acids and amines. They are characterized by moderate activity and can effectively avoid the activation of the α-position chiral center of...

The Ullman reaction was discovered by Ullman in 1903. It usually refers to a copper-catalyzed cross-coupling reaction between an aryl halide and a nucleophile such as oxygen, nitrogen, sulfur, phosphorus or carbon. This reaction not only requires the use of an excess of copper catalyst, but also requires high temperature...