Aromatic alkynes are active intermediates formed by the partial overlap of sp2 orbitals of two carbon atoms ortho to an aromatic ring. This structure can efficiently achieve ortho difunctionalization of aromatic rings. For example, the currently widely used Kobayashi aryne precursor can functionalize two groups at the 1,2-position of the...

Studying the spatial distribution of proteomes in cells is of great significance for elucidating many molecular mechanisms in cell biology. In recent years, proximity chemical labeling technology represented by APEX (The engineered ascorbate peroxidase) has developed rapidly, achieving proximity labeling of proteins and RNA in specific spatial regions within a...

Trifluoromethyl is an important structure. Introducing it into organic compounds can improve the polarity, dipole moment, stability, and lipophilicity of the target product. Therefore, compounds containing trifluoromethyl are widely used in medicines and pesticides. , new materials and other fields are of great significance. Methyl fluorosulfonyl difluoroacetate (also known as...

Alkaline phosphatase (ALP) is a hydrolase that is widely present in human liver and bones [1] . The ALP content in human serum is an important indicator for the diagnosis of liver diseases such as liver cancer and bone diseases, and has very important clinical significance [2-3].The precipitation-type ALP fluorescent...

Gold nanorods are rod-shaped gold nanoparticles with dimensions ranging from a few nanometers to hundreds of nanometers. They have rich and unique physical and chemical properties. They have a high surface electric field intensity enhancement effect and continuously adjustable photothermal conversion efficiency. Therefore, they are widely used in It has...

5-methylcytosine modification (5mC) is one of the important epigenetic modifications in eukaryotic cell genomes. 5mC can be gradually oxidized to 5-hydroxymethylcytosine (5hmC), 5-aldehydecytosine (5fC) and 5-carboxycytosine (5caC) under the action of TET family enzymes; for the above-mentioned several new DNA modifications Functional research is currently a hot spot in nucleic...