Professor Zhang Yongqiang of Shandong University has developed a series of (Salen)Ti catalysts. This series of catalysts has a deep chiral environment, excellent enantioselective control, and covers the dual functions of chiral Lewis acids and chiral metal radicals. It can be used in many applications. A variety of chemical transformations with high enantioselectivity [1-3], such as asymmetric hydrogen atom transfer reduction reaction of glycidic acid esters, asymmetric allylation reaction of glycidic acid esters, etc. Such catalysts help achieve excellent enantioselective control in organic synthetic transformations.

Figure 1 (Salen)Ti catalyst with deep chiral environment

Application examples

With the help of (Salen)Ti catalyst in a deeply chiral environment, a highly enantioselective allylation reaction of epoxy compounds was achieved, and a chiral all-carbon quaternary carbon structure that was extremely challenging to synthesize was constructed; epoxy compounds were developed catalytic asymmetric hydrogen atom transfer reaction to construct a chiral tertiary carbon structure.

Figure 2 (Salen)Ti catalyst catalyzes highly enantioselective allylation and hydrogen atom transfer reactions of epoxy compounds

Zhang Yongqiang is a professor and doctoral supervisor at Shandong University. He was selected into the National Overseas High-level Young Talent Project, a Humboldt Scholar in Germany, a Taishan Young Scholar in Shandong Province, and an outstanding young and middle-aged scholar in Shandong University. Currently, he is mainly engaged in research on asymmetric radical reactions catalyzed by pre-transition metals (titanium), bioactive molecule synthesis, medicinal chemistry, etc. He is currently the corresponding/first author in J. Am. Chem. Soc., Angew. Chem. Int. . Ed. and other internationally renowned journals have published many papers.

J&K Scientific exclusively supplies the deep chiral environment (Salen) Ti catalyst developed by Professor Zhang Yongqiang of Shandong University. The product advantages are as follows:
Excellent enantioselectivity control;
Wide substrate range and high catalytic efficiency;
Soluble in organic solvents, stable in nature, insensitive to water and air, and easy to preserve;

Product list

References

Shen J, Xu Z, Yang S, et al. Quaternary Stereocenters via Catalytic Enantioconvergent Allylation of Epoxides[J][J][J]. Synthesis, 2023.