In 2016, Professor Hong Xuechuan of Wuhan University published an article in the journal Nature Materials [1], successfully synthesizing for the first time a near-infrared fluorescence II region that can be used to label a variety of biomolecules and can be metabolized by organisms ( NIR-II) small molecule dye - CH1055.

Its maximum emission wavelength is between 1000nm and 1600nm, and it has biocompatibility and imaging sensitivity such as non-toxic and absorbable. It can be used as an infrared window second reporter molecule for in vitro detection and in vivo imaging (Figure 1). It can also be used to detect cell markers, tissue specimens, early diagnosis of disease, disease staging, intraoperative navigation treatment, postoperative efficacy evaluation, etc. [2-10 ].

Bailingwei exclusively sells the near-infrared II region small molecule fluorescent dye developed by Professor Hong Xuechuan - CH1055 and its derivatives:

Modifiable: Modifiable sites have been added to connect bioactive substances to improve their water solubility and biocompatibility;
Metabolizable: The organism can absorb, metabolize, and excrete it through the kidneys;
Compared with traditional near-infrared II region fluorescent dyes, such as single-walled carbon nanotubes (SWNTs), quantum dots and other inorganic materials, CH1055 has better biocompatibility, in vivo metabolism and in vivo safety;
Compared with near-infrared I region (700-1000nm) fluorescent dyes, CH1055 has stronger penetrating ability into biological tissues, up to about 40μm; the imaging signal-to-noise ratio and resolution are higher.

Figure 1 Small molecule dyes in the near-infrared II region are used for in vivo imaging [4]

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References

1. Alexander L. Antaris, Xuechuan Hong. et al. Nat. Mater. 2016, 15(2), 235–242.
2. Alexander L. Antaris, Xuechuan Hong. et al. Nat. Commun. 2017, 8, 15269.
3. Shuqing He, Jun Song. Chem. Soc. Rev. 2018, 47, 4258-4278.
4. Bingbing Ding, Xuechuan Hong. et al. J. Med. Chem. 2019, 62, 2049−2059.
5. Yao Sun, Xuechuan Hong. et al. Chem. Sci. 2018, 9, 2092–2097.
6. Jiacheng Lin, Xuechuan Hong. et al. Chem. Sci. 2019, 10, 1219-1126.
7. Yao Sun, Xuechuan Hong. et al. Chem. Sci. 2017, 8, 3489-3493.
8. Yao Sun, Xuechuan Hong. et al. Chem. Sci. 2016, 7，6203-6207.
9. Xiaodong Zeng, Xuechuan Hong. et al. Adv. Healthcare Mater. 2018, 7, 1800589.
10. Hui Zhou, Xuechuan Hong. et al. J. Mater. Chem. C 2019, 7, 9448-9454.