A Fluorogenic Probe for Ultrafast and Reversible Detection of Formaldehyde in Neurovascular Tissues PFM (Fig. 1) is a fluorogenic probe suitable for the detection of formaldehyde in living cells with excellent temporal and spatial resolution.  Fluorescent probes based on regular fluorophores usually suffer from a low cell permeability and an...

Novel chiral phosphite ligands with stable properties, mild reaction conditions, high catalytic yields and enantioselectivity. Chirality is closely related to life phenomena and significantly affects material properties. Our demand for optically active substances has led to rapid progress in the research and development of chiral compounds. Dr. Lailai Wang has...

Vinylboronates and alkylboronates are key components in variegated transformations in all facets of chemical science. IMDN-Tf achieves fluoroalkylation-borylation in one step under mild reaction conditions. IMDN-Tf (Fig. 1), developed by Prof. Yi Pan of Nanjing University, is a trifluoromethylation reagent which can release trifluoromethyl radicals under photocatalytic conditions. In addition, boron...

Homogeneous HA/HC Polysaccharides Hyaluronan (HA) and chondroitin (CH) are two important Glycosaminoglycans that widely exist on the cell surface and in the extracellular matrix. They are able to interact with cytokines, cell adhesion molecules, selectins and enzymes to regulate intracellular signaling pathways [1]. Also, they have various applications in pharmaceuticals...

The Mitsunobu reaction uses triphenylphosphine (PPh3) and diethyl azodicarboxylate (DEAD) to convert a 1° or 2° alcohol into a wide variety of final products, dependent on the mildly acidic nucleophile (H-Nuc) used. H-Nuc transfers its proton to the zwitterionic adduct formed from PPh3 attacking the DEAD. The resulting phosphonium intermediate...

Negishi cross coupling The use of organozinc reagents in the Negishi (Pd- or Ni-catalyzed) cross-coupling reaction with organohalides allows for a much greater functional group tolerance than in the Kumada cross-coupling reaction. Other benefits include high reactivity, high regio- and stereoselectivity, few side reactions and little toxicity. Unlike the addition...