The Kumada cross-coupling reaction uses a palladium or nickel catalyst to couple an organohalide and a Grignard or organolithium reagent. The mechanism follows the expected oxidative addition-reductive elimination cycle. Reagents: Catalytic Palladium or Nickel Reactant: Organohalide, Organomagnesium or Organolithium Product: Coupled Product Type of Reaction: C-C Cross-Coupling Lab Tips Organolithium...

1.  Planning Experiments Avoid storing organolithium compounds, use them promptly after purchase. If storage is required, do so in an explosion-proof fridge that maintains a temperature of 10°C or lower. Become acquainted with your reagents before beginning to work with them; review SDS information for more information about storage, handling,...

Polyadenylic acid (also known as poly(A), poly(A) carrier or carrier RNA) is a synthetic homopolymer composed of a long single-stranded (100-500 kDa) sequence of adenine (A) nucleotides available in lyophilized form. Its charge, shape and ability to residue-stack is modulated by solvent composition. It is structurally identical to poly(A) tails,...

What are Organolithium Compounds? Organolithium compounds (RLi) are organometallic compounds that contain carbon – lithium bonds. Unlike Grignard reagents which inserts between the carbon and halide bond, Lithium replaces the halide to form organolithium, forming a stronger partial negative charge on the carbon. Organolithium reagents act as good “nucleophilic carbons”...

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The Finkelstein reaction uses acetone and a metal halide salt to exchange the halogen atom of an alkyl halide for another halogen atom via an SN2 reaction. The substituted metal halide being less soluble than the original metal halide in acetone (Le Chatelier’s principle) drives the reaction forward. Reagents: Acetone,...