A Fluorescent Multifunction Hantzsch Ester (4-(3-((2-(Methacryloyloxy)ethoxy)carbonyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin-4-yl)phenyl)boronic acid, 99% CAS: 2242502-13-0Cat. No.: 9172863   Dr. Tao has developed a multifunctional Hantzsch ester (9172863) with promising applications.   Hantzsch ester 9172863 can be polymerized by reacting with poly(ethylene glycol methyl ether) methacrylate (PEGMA). This fluorescent polymer could be used for biomedical research to tag, for...

2/3 of human proteins can be phosphorylated. The signal network of phosphorylation sites provides information to determine physiological status of cells, identify disease markers, and discover drug targets. Achieving higher specific enrichment of phosphoproteins or phosphopeptides would reduce sample complexity, suitable for applications such as MS-based phosphoproteome analysis. For this...

Second region near-infrared (NIR-II) fluorescence imaging has been used widely in vivo due to its long excitation wavelength and the ability to achieve deep penetration depths, and high spatial resolution. However, existing NIR-II fluorescent probes, such as single-walled carbon nanotubes (SWNTs), quantum dots, rare-earth nanoparticles, and other inorganic materials or...

Popular since the early 1900s, the 1,4-addition of Michael donors to activated π-systems (called Michael acceptors) to form new C-C bonds is known as the Michael addition or reaction. With the help of a base, the donor is converted to an enolate ion, which attacks the Michael acceptor. When a...

The Mukaiyama aldol reaction uses a catalytic Lewis acid (e.g. TiCl4) or base, and an aqueous work-up to convert an aldehyde and an E- or Z-enol silane to an anti- and/or syn-diastereomer 1,3-ketol. The aldehyde is activated for nucleophilic attack when it coordinates to the Lewis acid, releasing a chloride...

The use of organozinc reagents in the Negishi (Pd- or Ni-catalyzed) cross-coupling reaction with organohalides allows for a much greater functional group tolerance than in the Kumada cross-coupling reaction. Other benefits include high reactivity, high regio- and stereoselectivity, few side reactions and little toxicity. Unlike the addition of a base...