The TPQL-1 and TPQL-2 fluorescent dyes, developed by the Zhang Xiaobing-Yuan Lin research group at Hunan University, are innovative two-photon dyes designed through a single-atom substitution and electron acceptor combination strategy based on the 6-ethyl-2-dimethylaminonaphthalene (acedan) structure (Figure 1). [1]

In recent years, two-photon fluorescent dye imaging has gained widespread adoption due to its advantages in deep tissue penetration (up to 1,000 μm) and low tissue absorption. This technology effectively reduces photodamage, photobleaching, and background fluorescence, enabling high-precision imaging and biomolecule detection in complex biological systems. [2]

Figure 1  TPQLs Fluorescent dyes [1][1]

Professor Yuan Lin is a professor and doctoral supervisor at the School of Chemistry and Chemical Engineering, Hunan University and the State Key Laboratory of Chemical Biosensing and Metrology.Currently, he has published more than 100 papers in international academic journals, with a total citation of more than 12,000 times, and an h-index of 58.Among them, the first or corresponding author from 2012 to presentJ. Am. Chem. Soc.（10 articles）、 Nat. Commun.（1 articles）、 Angew. Chem. Int. Ed.（10 articles）、CCS Chem.（1 articles）、Chem. Sci.（4 articles）、Anal. Chem.（10 articles）、Adv. Funct. Mater、BiomaterialsPublished more than 70 papers in journals and other journals. Mainly engaged in research on small molecule fluorescent probes and their applications.