Benzo[a][a][a]pyrene-7,8-dihydrodiol-9,10-epoxide, BPDE). This metabolite has two pairs of enantiomers: (±)anti-BPDE and (±)syn-BPDE. A large number of studies have shown that (±)anti-BPDE is more mutagenic than (±)syn-BPDE. ) anti-BPDE mainly binds to the N-2 position of deoxyguanosine in the DNA of organisms to generate the deoxyguanosine adduct of BPDE (anti-BPDE-dG) [1-2][1-2].

Yan Xiaoqing, associate professor and master's tutor at Shanxi Medical University, is mainly engaged in theoretical research on the weak intermolecular forces of halogen bonds and π-hole bonds and their application in the fields of solid phase extraction and chromatographic separation, providing high-efficiency selective adsorption and chromatographic detection. Environmental pollutants and their DNA adducts offer new mechanisms and strategies.

Associate Professor Yan Xiaoqing of Shanxi Medical University has developed a new synthesis and separation method, which introduces new forces to rapidly separate and purify four anti-BPDE-dG isomers in a short time. The separation speed is 2.5 times higher than the existing technology, and the synthesis yield is Compared with the existing method, it is more than 2 times higher, and the production cost and time are greatly reduced.

J&K exclusively supplies the anti-BPDE-dG isomer standard developed by Associate Professor Yan Xiaoqing, which can be directly used in BPDE-DNA adduct analysis and research, facilitating its application in environmental analysis, occupational population monitoring and other research fields.

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references

Ai-Xiang Liu, Xin Li, Li-Sha Zhou, Xiao-Qing Yan, Na Xia, Zhan-Fei Song, Jing-Jing Cao, Zhong-Suo Hao, Zhi-Hong Zhang, Rui-Feng Liang, Hong-Mei Zhang. Environ Sci Pollut Res. 2023, 30, 106549-106561.
Ling Guo, Xiao Jiang, Hao-Yuan Tian, Shang-Jin Yao, Bo-Ya Li, Rong-Jie Zhang, Shu-Sheng Zhang, Xin Sun, Journal of Food and Drug Analysis, 2019,27, 518-525.