Click Chemistry is a synthesis concept proposed by Sharpless, a Nobel Prize winner in chemistry from the United States, in 2001 [1]. Among them, the main and classic click chemical reaction is the Cu(I)-catalyzed azide-alkynyl Husigen cycloaddition reaction (CuAAC). This reaction has the advantages of high yield, few side reactions, and mild reaction conditions. It is widely used in pharmaceuticals. It has very broad application prospects in many fields such as development, biomedical materials, and biological macromolecules.

Li Xuebing, a researcher at the Institute of Microbiology, Chinese Academy of Sciences, is committed to the research on sugar chain synthesis methodology and the development of new methods to inhibit pathogenic microorganisms and rapid detection of pathogenic microorganisms based on sugar chain synthesis. He has successfully developed a catalyst ligand for the CuAAC reaction. .

Among biomolecule markers, the CuAAC reaction catalyst ligand [Figure 1, BTTAA (Cat. No.: 9058700)] is a very effective accelerating ligand. When used in the CuAAC reaction, it can not only increase the reaction rate, but also further reduce the catalyst The usage amount of Cu(I) greatly reduces the toxicity to cells or organisms [2][2]

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References

1.Hartmuth C. Kolb, M. G. Finn, K. Barry Sharpless. Angew. Chem., 2001, 113, 2056-2075.
2.Chayasith Uttamapinant, Anupong Tangpeerachaikul, Scott Grecian, Scott Clarke,Upinder Singh, Peter Slade, Kyle R. Gee, Alice Y. Ting. Angew. Chem. Int. Ed., 2012, 51, 5852-5856.