Fluorine is an important non-metal element. Due to its unique electronegativity, electronic effect and steric hindrance effect, fluorine atoms are often introduced into drugs to regulate drug metabolism pathways, improve metabolic stability and permeability, etc., and have been More than 20% of drugs and pesticides on the market contain one or more fluorine atoms. The green and efficient synthesis of fluoride has become a research hotspot in fluorine chemistry. Researcher Hu Jinbo introduced two new fluorination reagents - sodium difluoromethylsulfinate and sodium monofluoromethylsulfinate. Both are colorless solids with stable properties and can react with appropriate oxidants. Alkenes, heteroatoms, isocyanates, aromatic heterocycles, cyclopropanes, etc. undergo free radical reactions to generate corresponding products containing CF2H or CH2F, which is easy to operate.

      J&K Scientific can provide reagents required for the synthesis and transformation methodology research of a variety of fluorine-containing compounds:

      Full range: covering fluorination reagents, fluorine-containing building blocks, catalysts and ligands, alkynes, boron-containing compounds, organometallic reagents, synthetic reagents, etc. We also provide supporting inorganic reagents, ultra-dry solvents, nuclear magnetic solvents and common instrument consumables. ;


      New products: new fluorinated reagents that can be used to transform the scientific research results of scientists in this field;


      Quality assurance: high purity, strict quality control, and stable batch quality.

      Recommended products

Product name CAS Item number
Sodium difluoromethanesulfinate, 98% 275818-95-6 2465675
Sodium fluoromethanesulfinate, 98% 1661836-10-7 2465682

 

      Fluorine building blocks

Product name CAS Item number
Benzotrifluoride, 99%, SuperDry, water≤10 ppm, J&KSeal 98-08-8 350291
Hazardous chemicals
3-Fluorosalicylaldehyde, 99% 394-50-3 107326
Pentafluorobenzene, 99% 363-72-4 446634

 

      Catalysts and ligands

Product name CAS Item number
Bis(1,5-cyclooctadiene)nickel(0), 98% 1295-35-8 112324
Copper(I) iodide, 98% 7681-65-4 988790
Tetrakis[(R)-(-)-][(1R)-1-(4-bromophenyl)-2,2-diphenylcyclopropanecarboxylato]dirhodium(II) Rh2(R-BTPCP)4 1345974-62-0 45-2080

 

      Photocatalyst

Product name CAS Item number
Eosin Y 15086-94-9 985235
Rhodamine 6G, indicator 989-38-8 151183
Tris(2-phenylpyridine)iridium, 99%, for synthesis 94928-86-6 997766

 

      Alkynes

Product name CAS Item number
5-Decyne, 98% 1942-46-7 995332
3-Methyl-1-butyne, 95% 598-23-2 796593
1-Phenyl-1-butyne, 97% 622-76-4 920562

 

      Boron compounds

Product name CAS Item number
4-Formylphenylboronic acid, 97% 87199-17-5 277581
Phenylboronic acid, 99% 98-80-6 390913

 

      Organometallic reagents

Product name CAS Item number
n-Butyllithium, 1.6 M solution in hexanes, J&KSeal 109-72-8 274232
Lithium bis(trimethylsilyl)amide, 1.0 M solution in THF, J&KSeal 4039-32-1 932250
Phenyllithium, 1.5-1.7M in cyclohexane/ether, 70:30%, packaged under Argon in resealable ChemSeal^t bottles 591-51-5 043259

 

      Synthetic reagents

Product name CAS Item number
Chlorotrimethylsilane, 98%, J&Kseal 75-77-4 932010
Hazardous chemicals
Iodomethane, 99%, stabilized with copper chip 74-88-4 395069
Hazardous chemicals
Sodium iodide, 99%, for analysis 7681-82-5 191037

 

      General product

Product name CAS Item number
Benzene, 99.7%, HPLC grade 71-43-2 335612
Hazardous chemicals
Dichloromethane-d2, 99.8 atom%D 1665-00-5 334919
Iridium(III) chloride hydrate, 50 - 58% Ir 14996-61-3 110534
By 向阳 翟

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