Mitochondria-Targeted Research with IR-780 Ethyl Iodide

Mitochondria are fundamental organelles in eukaryotic cells, playing a crucial role in energy metabolism. Positively charged dyes are commonly used for mitochondrial labeling in living cells, offering innovative methods to study mitochondrial metabolic processes.

IR-780 Ethyl Iodide (λex = 780 nm, λem = 830 nm) stands out as a highly selective dye for mitochondria. Its unique properties and versatile modification sites enable its use in constructing activated fluorescent probes or designing novel mitochondria-targeted probes. These applications facilitate the detection of active biomolecules, cellular damage, and disease-associated organ dysfunction in cells and in vivo settings【1-3】.

Key Applications of IR-780 Ethyl Iodide：

Fluorescent Probes:

• IR-780 Ethyl Iodide’s modification sites allow for the construction of targeted fluorescent probes, aiding research into cellular and mitochondrial activity.

• This dye delivers excellent staining for sentinel lymph nodes and exhibits remarkable stability【4】.

Cancer Research:

• Specific accumulation in cancer cell mitochondria makes IR-780 Ethyl Iodide valuable for cancer diagnosis and therapy【6】.
• It characterizes human cancer stem cells (CSCs) through the activity of the HIF-1α/glycolysis-dependent mitochondrial transporter ABCB10【5】.

Biomedical Imaging:

• IR-780 Ethyl Iodide can detect mitochondrial dysfunction and active biomolecules, broadening its utility in disease research and therapeutic monitoring.

Professor Wang Qin, from the School of Chemistry and Environmental Sciences at Shaanxi University of Science and Technology, specializes in nanofluorescent probe construction and application. He has published extensively in SCI-indexed journals, with nine papers as the first author. Professor Wang has also contributed to two National Natural Science Foundation projects, advancing research in fluorescent probes and their biomedical applications.

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