Intraoperative fluorescence navigation is a technology that utilizes the enhanced penetration and retention effect (EPR effect) of fluorescent dyes. After accumulation in tumor tissue, it emits fluorescence by receiving excitation light to display the location of the tumor in real time.
Because it can improve the accuracy and safety of surgery, reduce surgical trauma and recovery time, fluorescence navigation surgery is widely used in various surgeries, such as tumor resection, vascular surgery, neurological surgery, etc.

Figure 1 Fluorescence imaging technology has broad application prospects in intraoperative navigation due to its advantages such as easy operation, high resolution, good safety, and real-time imaging. [1]

According to the emission wavelength of the fluorescent contrast agent, near-infrared fluorescence can be divided into near-infrared first region (NIR-Ⅰ) fluorescence in the range of 700 to 1,000 nm and near-infrared second region (NIR-Ⅱ) in the range of 1,000 to 1,700 nm. Fluorescence, currently ICG-based NIR-Ⅰ and NIR-Ⅱ fluorescence navigation technologies have been used to guide tumor resection.
Bailingwei provides near-infrared first zone (NIR-Ⅰ) fluorescent dyes to assist intraoperative navigation.

Professor Yang Youjun’s scientific research achievements | EC series near-infrared fluorescent dyes - high fluorescence intensity and good photostability

EC835, 97%, Near-infrared fluorescent dye, liposoluble

Indocyanine green (ICG) reactive derivatives—near-infrared I-region fluorescent dyes that can modify and label biological macromolecules

The main application areas of ICG and its derivatives include: (1) ophthalmic angiography; (2) perfusion diagnosis of tissues and organs; (3) sentinel lymph node biopsy of tumors; (4) near-infrared fluorescence/photoacoustic dual-modal imaging; (5) Photodynamic/photothermal therapy synergistic treatment[1-4]
J&K Scientific provides 15 kinds of indocyanine green (ICG) active derivatives - which can modify and label biological macromolecules with a purity of ≥95%.

references

1. [1]Yunxue Xu, Renfu Liu, Kun xu, Zhifei Dai. Fluorescent Probes for Intraoperative Navigation[J]. Progress in Chemistry, 2021, 33(1): 52-65.