Asymmetric catalysis is one of the research hotspots in the field of organic synthesis. According to the type of catalyst, it can be divided into metal complex catalysis, organic small molecule catalysis and enzyme catalysis. Chiral ligands are crucial for metal complex catalysts, but most ligands have narrow application ranges, limiting their applications.
Feng Xiaoming's research group at Sichuan University has been committed to research on asymmetric catalysis for the past 20 years, designed flexible chiral nitrogen-oxygen ligands, and carried out systematic and in-depth research work. Currently, this type of ligand can form complexes with more than 20 metal ions (including main group metals, transition metals and rare earth metals), catalyze more than 50 types of asymmetric reactions, and provides a simple and efficient new way to synthesize chiral molecules. Professor Noyori, Nobel Prize winner in Chemistry, commented that it “represents a class of dominant chiral ligands”.
Figure 1 Representative asymmetric reactions involving Feng's chiral dinitroxide ligand-metal complex[1]
Its advantages are as follows:
Strong broad spectrum: it can be used as an organic small molecule catalyst, or as a ligand to form a complex catalyst with a variety of metals, both showing excellent stereoselectivity;
Adjustable structure: both rigid and flexible, and can be modified with substituents according to reaction requirements;
Good solubility and stable properties: soluble in both polar and non-polar solvents, insensitive to water and air, and can react at room temperature.
Bailingwei exclusively supplies Feng's chiral nitroxide ligand series products with high purity and sufficient stock. It also provides a variety of metal salts, chiral oxazoline ligands and solvents.
Feng's chiral nitroxide ligand
Feng's ligand piperidine skeleton
NO-Feng-PDiPPPi, L-PiPr2, 99%
NO-冯-PDiPPPi
CAS：1000051-40-0
Item number：1595285
NO-Feng-PTMPPP, L-PiMe3, 99%
NO-冯-PTMPPP
CAS：1310585-10-4
Item number：1595286
NO-Feng-PDEtPPi, L-PiEt2, 95%
NO-冯-PDEtPPi
CAS：1313215-46-1
Item number：2699018
NO-Feng-PBuPPi, L-PitBu, 95%
NO-冯-PBuPPi
CAS：959152-93-3
Item number：2699022
NO-Feng-PPhPPi, L-PiPh, 95%
NO-冯-PPhPPi
CAS：945564-77-2
Item number：2699020
NO-Feng-PBnPPi, L-PiBn, 95%
NO-冯-PBnPPi
CAS：1085279-20-4
Item number：2699021
NO-Feng-PDEtMPPi, L-PiEt2Me, 95%
NO-冯-PDEtMPPi
CAS：1502814-74-5
Item number：2699019
NO-Feng-PCyPPi, L-PicH, 95%
NO-冯-PCyPPi
CAS：1017605-60-5
Item number：2699023
NO-Feng-PDMPPi, L-PiMe2, 95%
NO-冯-PDMPPi
CAS：1227411-35-9
Item number：2699017
NO-Feng-PDiPPPr, L-PrPr2, 99%
NO-冯-PDiPPPr
CAS：945564-85-2
Item number：1595283
NO-Feng-PDMPPy, L-PrMe2, 99%
NO-冯-PDMPPy
CAS：1330533-36-2
Item number：1595284
NO-Feng-PDPhMPPr, L-PrCPh2, 95%
NO-冯-PDPhMPPr
CAS：870716-88-4
Item number：2699016
NO-Feng-PDEtPPr, L-PrEt2, 95%
NO-冯-PDEtPPr
CAS：1313215-45-0
Item number：2699012
NO-Feng-PBnPPr, L-PrBn, 95%
NO-冯-PBnPPr
CAS：870716-86-2
Item number：2699014
NO-Feng-PPhPPr, L-PrPh, 95%
NO-冯-PPhPPr
CAS：945564-81-8
Item number：2699013
NO-Feng-PDEtMPPr, L-PrEt2Me 95%
NO-冯-PDEtMPPr
CAS：1502814-73-4
Item number：2699015
NO-Feng-PDiPPRa, L-RaPr2, 95%
NO-冯-PDiPPRa
CAS：1005495-74-8
Item number：1595287
NO-Feng-PDMPRa, L-RaMe2, 99%
NO-冯-PDMPRa
CAS：1132049-44-5
Item number：1595288
Metal Salts
| Product name | CAS | Item number |
|---|---|---|
| Copper(II) trifluoromethanesulfonate, 98% | 34946-82-2 | 208060 |
| Iron(II) trifluoromethanesulfonate, 98% (Iron triflate) | 59163-91-6 | 26-2830 |
| Lanthanum trifluoromethanesulfonate, 98% | 52093-26-2 | 526606 |
| Magnesium trifluoromethanesulfonate, 98% | 60871-83-2 | 152796 |
| Nickel(II) trifluoromethanesulfonate, 96% | 60871-84-3 | 810702 |
| Samarium(III) trifluoromethanesulfonate, 98% | 52093-28-4 | 246805 |
| Scandium(III) triflate, 98% | 144026-79-9 | 302513 |
| Ytterbium(III) trifluoromethanesulfonate, 98% | 54761-04-5 | 904954 |
Chiral Oxazoline Ligands
| Product name | CAS | Item number |
|---|---|---|
| 2,6-Bis[(4R)-4-phenyl-2-oxazolinyl]pyridine, 98% | 128249-70-7 | 299174 |
| 2,6-Bis[(4R)-(+)-isopropyl-2-oxazolin-2-yl]pyridine, 98% | 131864-67-0 | 353382 |
| 2,6-Bis[(4S)-(-)-isopropyl-2-oxazolin-2-yl]pyridine, 99% | 118949-61-4 | 358083 |
| 4-Bromo-2,6-bis[(4S)-4,5-dihydro-4-phenyl-2-oxazolyl]-pyridine, 95% | 1190936-03-8 | 1710789 |
Solvents
| Product name | CAS | Item number |
|---|---|---|
| 1,2-Dichloroethane, 99% | 107-06-2 | 353972 |
| 1,1,2,2-Tetrachloroethane, 98.5% | 79-34-5 | 470939 |
| Acetonitrile, 99.9%, SuperDry, water≤10 ppm, J&KSeal | 75-05-8 | 980779 |
| Benzotrifluoride, 99%, SuperDry, water≤10 ppm, J&KSeal | 98-08-8 | 350291 |
| Chlorobenzene, 99% | 108-90-7 | 292651 |
| Dichloromethane, 99.9%, SuperDry, with molecular sieves, water≤30 ppm, J&KSeal | 75-09-2 | 908525 |
| Ethyl acetate, 99.5%, SuperDry, J&KSeal | 141-78-6 | 954403 |
| Tetrahydrofuran, 99.5%, SuperDry, with molecular sieves, stabilized with 250 ppm BHT, J&KSeal | 109-99-9 | 974643 |
| tert-Butanol, 99.5%, ACS reagent | 75-65-0 | 926353 |
向阳 翟
