One-step Multi-functionalization of Aromatic Alkynes Aromatic alkyne allows efficient ortho di-functionalization of the aromatic ring. For example, the aryne precursor Kobayashi can functionalize two groups at the 1,2-position of the benzene ring. Would it be possible to achieve tri-functionalization of aromatic rings by aromatic alkynes? Dr. Yang Li has developed...

Novel chiral phosphite ligands with stable properties, mild reaction conditions, high catalytic yields and enantioselectivity. Chirality is closely related to life phenomena and significantly affects material properties. Our demand for optically active substances has led to rapid progress in the research and development of chiral compounds. Dr. Lailai Wang has...

Vinylboronates and alkylboronates are key components in variegated transformations in all facets of chemical science. IMDN-Tf achieves fluoroalkylation-borylation in one step under mild reaction conditions. IMDN-Tf (Fig. 1), developed by Prof. Yi Pan of Nanjing University, is a trifluoromethylation reagent which can release trifluoromethyl radicals under photocatalytic conditions. In addition, boron...

Homogeneous HA/HC Polysaccharides Hyaluronan (HA) and chondroitin (CH) are two important Glycosaminoglycans that widely exist on the cell surface and in the extracellular matrix. They are able to interact with cytokines, cell adhesion molecules, selectins and enzymes to regulate intracellular signaling pathways [1]. Also, they have various applications in pharmaceuticals...

A Fluorescent Multifunction Hantzsch Ester (4-(3-((2-(Methacryloyloxy)ethoxy)carbonyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin-4-yl)phenyl)boronic acid, 99% CAS: 2242502-13-0Cat. No.: 9172863   Dr. Tao has developed a multifunctional Hantzsch ester (9172863) with promising applications.   Hantzsch ester 9172863 can be polymerized by reacting with poly(ethylene glycol methyl ether) methacrylate (PEGMA). This fluorescent polymer could be used for biomedical research to tag, for...

2/3 of human proteins can be phosphorylated. The signal network of phosphorylation sites provides information to determine physiological status of cells, identify disease markers, and discover drug targets. Achieving higher specific enrichment of phosphoproteins or phosphopeptides would reduce sample complexity, suitable for applications such as MS-based phosphoproteome analysis. For this...