Glycosylation ReagentsDownload PDF
The synthesis of nucleosides has been a topical subject in efforts to develop new therapeutic agents (e.g., antitumor and antiviral drugs), to manipulate genetic processes (e.g. antisense oligonucleotides and RNA interference), and to expand the genetic code and understand the scope and limits of Watson–Crick base pairing. However, the key technique for such syntheses, namely, the N-glycosidic coupling of sugars and nitrogen heterocycles, is rather conventional. The bromo sugar used in the Koenigs-Knorr synthetic method has poor stability and is not easy to store. The synthetic method uses toxic mercury salt or expensive silver salt as a catalyst, and the yield is low [4,5]. The Glucosinolate method [6,7] and trichloroacetimidate ester method [8,9] have long routes, complex reaction conditions, expensive catalysts, lower yields and many other disadvantages.
J&K exclusively supplies a novel class of glycosylation reagents by gold (I)-catalyzed glycosylation reaction to sugar-o-alkynyl benzoate donor.The reaction can achieve efficient synthesis of a series of active oligosaccharides, glycoconjugates, nucleosides, deoxynucleosides, glycoproteins and other compounds. J&K provides:
- Stable donors, mild reacting conditions, with a wide range of saccharide receptors and no introduction of nucleophilic species. - Good stereoselectivity, with high yields and little side effects. - The unique reaction mechanism  to help achieve the synthesis of carbohydrate compounds.
References  Angew. Chem. Int. Ed. 2011, 50, 4933-4936.  J. Am. Chem. Soc. 2009, 131, 12076-12077.  J. Org. Chem., 2011, 76 (23), 9748–9756. Angew. Chem. Int. Ed. 2011, 50, 8329-8332.
Novel Glycosidated Donors
|1412669||2-(Cyclopropylethynyl)benzoic acid, 98%||1313028-09-9||Pricing|
|1412764||Methyl 2-(cyclopropylethynyl)benzoate, 98%||1357469-11-4||Pricing|
|1412684||Methyl 2-(hex-1-yn-1-yl)benzoate, 98%||462637-40-7||Pricing|
|502144||Bis(cyclopentadienyl)zirconium dichloride, 99%||1291-32-3||Pricing|
|1415906||Triphenylphosphinegold(I) bis(trifluoromethanesulfonyl)imidate, 98%||866395-16-6||Pricing|
|208060||Copper(II) trifluoromethanesulfonate, 98%||34946-82-2||Pricing|
|174441||Silver trifluoromethanesulfonate, 98%||2923-28-6||Pricing|
|976446||Triphenylphosphinegold(I) trifluoromethanesulfonate, 98%||156397-47-6||Pricing|
|942961||Bis(2-methoxyethyl)aminosulphur trifluoride, 95%||202289-38-1||Pricing|
|1000173||4-tert-Butyl-2,6-dimethylphenylsulphur trifluoride, 90%||947725-04-4||Pricing|
|102492||2-Chloro-1-methylpyridinium iodide, 97%||14338-32-0||Pricing|
|168478||Diethylaminosulfur trifluoride, 95%||38078-09-0||Pricing|
|221715||Methyl trifluoromethanesulfonate, 96%||333-27-7||Pricing|
|242768||Trifluoromethanesulfonic acid, 99%||1493-13-6||Pricing|
|264281||Trimethylsilyl trifluoromethanesulfonate, 99%||27607-77-8||Pricing|